Results for 'Thomas Bl Kirkwood'

953 found
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  1.  29
    The free‐radical theory of ageing – older, wiser and still alive.Thomas Bl Kirkwood & Axel Kowald - 2012 - Bioessays 34 (8):692-700.
    The continuing viability of the free‐radical theory of ageing has been questioned following apparently incompatible recent results. We show by modelling positional effects of the generation and primary targets of reactive oxygen species that many of the apparently negative results are likely to be misleading. We conclude that there is instead a need to look more closely at the mechanisms by which free radicals contribute to age‐related dysfunction in living systems. There also needs to be deeper understanding of the dynamics (...)
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  2.  27
    Human senescence.Thomas B. L. Kirkwood - 1996 - Bioessays 18 (12):1009-1016.
    Human life expectancy has increased dramatically through improvements in public health, housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic senescence and its associated frailty and diseases. Understanding the biological basis of the ageing process is a major scientific challenge that will require integration of molecular, cellular, genetic and physiological approaches. This article reviews progress that has been made to date, particularly with regard to the genetic contribution to senescence and longevity, and assesses the scale of (...)
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  3.  44
    Evolution of the human menopause.Daryl P. Shanley & Thomas B. L. Kirkwood - 2001 - Bioessays 23 (3):282-287.
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  4.  17
    P53 and Ageing: Too Much of a Good Thing?Thomas B. L. Kirkwood - 2002 - Bioessays 24 (7):577-579.
    A recent report by Tyner et al.1 suggests that p53 is bad for longevity. Heterozygotic mice carrying a p53 mutation that apparently enhances the stability of the wild‐type protein showed shorter lifespans and faster ageing while also developing fewer tumours. This fits with the idea that cellular ageing is the price paid for better protection against unlimited proliferation of cancer cells. But other work shows that there is a strong positive association between DNA repair‐mediated protection against cancer and ageing. So (...)
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  5.  18
    The Genetics of Old Age.Thomas B. L. Kirkwood - 2002 - In Justine Burley & John Harris (eds.), A Companion to Genethics. Wiley-Blackwell. pp. 43–50.
    The prelims comprise: Introduction Genetic Architecture of the Life Span Genetics of Longevity Genetics and the Future of Old Age Conclusion.
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  6.  27
    Increasing longevity: an important question, a dubious answer. The evolution of death: Why we are living longer. (2006). By Stanley Shostak. State University of New York Press, Albany 246 pp. ISBN: 07914694689. [REVIEW]Thomas B. L. Kirkwood - 2007 - Bioessays 29 (7):710-711.
  7.  18
    Book review: Becoming immortal: Combining cloning and stem‐cell therapy. [REVIEW]Thomas B. L. Kirkwood - 2004 - Bioessays 26 (1):106-107.
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  8.  22
    Mitochondria and ageing: winning and losing in the numbers game.João F. Passos, Thomas von Zglinicki & Thomas B. L. Kirkwood - 2007 - Bioessays 29 (9):908-917.
    Mitochondrial dysfunction has long been considered a key mechanism in the ageing process but surprisingly little attention has been paid to the impact of mitochondrial number or density within cells. Recent reports suggest a positive association between mitochondrial density, energy homeostasis and longevity. However, mitochondrial number also determines the number of sites generating reactive oxygen species (ROS) and we suggest that the links between mitochondrial density and ageing are more complex, potentially acting in both directions. The idea that increased density, (...)
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  9.  3
    Biology of ageing.Olivier Toussaint, José Remacle, Brian F. C. Clark, Efstathios S. Gonos, Claudio Franceschi & Thomas B. L. Kirkwood - 2000 - Bioessays 22 (10):954-956.
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  10.  22
    Frances McSparran, ed., Octovian Imperator, ed. from MS BL Cotton Caligula A II. Heidelberg: Carl Winter, 1979. Paper. Pp. 123. DM 38. [REVIEW]Thomas J. Heffernan - 1981 - Speculum 56 (2):458.
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  11.  81
    Residuated lattices arising from equivalence relations on Boolean and Brouwerian algebras.Thomas Vetterlein - 2008 - Mathematical Logic Quarterly 54 (4):350-367.
    Logics designed to deal with vague statements typically allow algebraic semantics such that propositions are interpreted by elements of residuated lattices. The structure of these algebras is in general still unknown, and in the cases that a detailed description is available, to understand its significance for logics can be difficult. So the question seems interesting under which circumstances residuated lattices arise from simpler algebras in some natural way. A possible construction is described in this paper.Namely, we consider pairs consisting of (...)
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  12.  37
    The Long‐term Unemployed: A New Protected Class of Employee?Thomas A. Hemphill, Waheeda Lillevik & Francine Cullari - 2012 - Business and Society Review 117 (4):535-553.
    Since the onset of the latest United States (U.S.) recession (beginning in December 2007), the U.S. economy has been posting high unemployment levels consistently exceeding 8 percent. Of specific interest, the U.S. Department of Labor, Bureau of Labor Statistics (BLS), reports on a specific subset of the U.S. unemployed: the long‐term unemployed, defined as those who are unemployed for 27 weeks and over. Since December 2009, the share of the long‐term unemployed of the total U.S. unemployed has exceeded 40 percent (...)
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  13.  58
    A Way to Interpret Łukasiewicz Logic and Basic Logic.Thomas Vetterlein - 2008 - Studia Logica 90 (3):407-423.
    Fuzzy logics are in most cases based on an ad-hoc decision about the interpretation of the conjunction. If they are useful or not can typically be found out only by testing them with example data. Why we should use a specific fuzzy logic can in general not be made plausible. Since the difficulties arise from the use of additional, unmotivated structure with which the set of truth values is endowed, the only way to base fuzzy logics on firm ground is (...)
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  14.  25
    Shaping Knowledge about American Labor: External Advising at the U.S. Bureau of Labor Statistics in the Twentieth Century.Thomas A. Stapleford - 2010 - Science in Context 23 (2):187-220.
    ArgumentCreated in 1884, the U.S. Bureau of Labor Statistics has been the major federal source for data in the United States on labor-related topics such as prices, unemployment, compensation, productivity, and family expenditures. This essay traces the development and transformation of formal and informal consulting relationships between the BLS and external groups over the twentieth century. Though such a history cannot, of course, provide a comprehensive analysis of how political values have shaped the construction of labor statistics during this period, (...)
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  15.  24
    Thomas Scott of Canterbury (1566–1635): Patriot, civic radical, puritan.Cesare Cuttica - 2008 - History of European Ideas 34 (4):475-489.
    This article sheds new light on the interesting but little-studied figure of Thomas Scott of Canterbury (1566–1635). In presenting Scott's ideas I will modify the interpretation laid out by Peter Clark whose groundbreaking study, ‘Thomas Scott and the Growth of Urban Opposition to the Early Stuart Regime’, is still the only secondary source that pays detailed attention to Scott and his thought, especially his religious opinions. The necessity to revisit Clark's interpretation of Scott's place within the political and (...)
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  16.  38
    Adorno's Aesthetic Theory: The Redemption of Illusion.Thomas Huhn - 1992 - Journal of Aesthetics and Art Criticism 50 (3):251-252.
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  17.  20
    Laudatio.Timothy B. Noone - 2010 - Franciscan Studies 68 (1):259-264.
    In lieu of an abstract, here is a brief excerpt of the content:LaudatioTimothy B. Noone (bio)On Sunday, July 26, 2009, the Franciscan Institute was pleased to award to Dr. Girard J. Etzkorn its 22nd Franciscan Institute Medal in recognition of a lifetime of scholarship, editing and publication of texts on medieval philosophy and theology, with a special emphasis on the Franciscan intellectual tradition. The ceremony was held in the Trustees Room of Doyle Hall on the campus of St. Bonaventure University (...)
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  18. Presence in absence. The ambiguous phenomenology of grief.Thomas Fuchs - 2018 - Phenomenology and the Cognitive Sciences 17 (1):43-63.
    Despite its complex experiential structure, the phenomenon of grief following bereavement has not been a major topic of phenomenological research. The paper investigates its basic structures, elaborating as its core characteristic a conflict between a presentifying and a ‘de-presentifying’ intention: In grief, the subject experiences a fundamental ambiguity between presence and absence of the deceased, between the present and the past, indeed between two worlds he lives in. This phenomenological structure will be analyzed under several aspects: regarding bodily experience, as (...)
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  19.  16
    Macphail (1987) Revisited: Pigeons Have Much Cognitive Behavior in Common With Humans.Thomas R. Zentall - 2021 - Frontiers in Psychology 11.
    The hypothesis proposed by Macphail is that differences in intelligent behavior thought to distinguish different species were likely attributed to differences in the context of the tasks being used. Once one corrects for differences in sensory input, motor output, and incentive, it is likely that all vertebrate animals have comparable intellectual abilities. In the present article I suggest a number of tests of this hypothesis with pigeons. In each case, the evidence suggests that either there is evidence for the cognitive (...)
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  20.  33
    What to do about peer review: Is the cure worse than the disease?Thomas R. Zentall - 1991 - Behavioral and Brain Sciences 14 (1):166-167.
  21.  3
    (1 other version)On the nonboundability of total effective operators.Thomas Zeugmann - 1984 - Mathematical Logic Quarterly 30 (9‐11):169-172.
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  22.  29
    Benedikt Strobel, Georg Wöhrle, Hrsg., Xenophanes von Kolophon.Thomas Zimmer - 2019 - Bochumer Philosophisches Jahrbuch Fur Antike Und Mittelalter 22 (1):215-217.
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  23.  20
    Tim Gollasch, Der Mythos von der Wirklichkeit. Eine Konfrontation des neurowissenschaftlichen Konstruktivismus mit Platons Philosophie.Thomas Zimmer - 2018 - Bochumer Philosophisches Jahrbuch Fur Antike Und Mittelalter 21 (1):211-215.
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  24.  13
    Urbanitas in der Kultur des westlichen Mittelalters.Thomas Zotz - 2011 - Frühmittelalterliche Studien 45 (1).
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  25.  14
    Rational Preference Utilitarianism.Thomas Young - 1988 - Philosophy in Context 18:19-27.
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  26. The Possibility of Practical Reason.Thomas Pink - 2003 - Mind 112 (448):812-816.
  27.  21
    The Treatise on Human Nature: Summa Theologiae 1a, 75-89.Thomas Aquinas - 2002 - Hackett Publishing Company.
    This series offers central philosophical treatises of Aquinas in new, state-of-the-art translations distinguished by their accuracy and use of clear and nontechnical modern vocabulary. Annotation and commentary accessible to undergraduates make the series an ideal vehicle for the study of Aquinas by readers approaching him from a variety of backgrounds and interests.
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  28.  60
    (1 other version)On perceptual aboutness.Thomas Natsoulas - 1977 - Behaviorism 5 (1):75-97.
  29.  78
    Undivided Corporate Responsibility: Towards a Theory of Corporate Integrity.Thomas Maak - 2008 - Journal of Business Ethics 82 (2):353-368.
    In the years since Enron corporate social responsibility, or “CSR,” has become a ubiquitous phenomenon in both research and business practice. CSR is used as an umbrella term to describe much of what is done in terms of ethics-related activities in firms around the globe to such an extent that some consider it a “tortured concept” (Godfrey and Hatch 2007, Journal of Business Ethics 70, 87–98). Addressing this skepticism, I argue in this article that the focus on CSR is indeed (...)
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  30.  8
    Assimilation and Resistance: Catholic Intellectuals and the Progressive Era.Thomas E. Woods - 2000 - Catholic Social Science Review 5:297-312.
    A new public philosophy began to emerge in the United States during the Progressive Era. Promoted by such intellectuals as John Dewey, William James, and the coUectivists of the New Republic magazine, it called for a citizenry trained in an experimental milieu, free of dogma and emancipated from sources of allegiance other than the new centralized democratic state then being forged. Catholics, however, neither capitulated to the new creed nor retreated into a self-righteous isolation. In a culture whose chief value (...)
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  31. The instrument Maker.Thomas Woody - 1957 - In Frederick C. Gruber (ed.), Foundations of education. Philadelphia: University of Pennsylvania Press.
     
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  32.  50
    Moral bioenhancement, freedom and reasoning.Thomas Douglas - 2014 - Journal of Medical Ethics 40 (6):359-360.
    This issue includes a number of papers on reproductive ethics, broadly construed. In a recent book, Anja Karnein proposed that embryos created in vitro should be offered up for adoption before being discarded or used in research;1 here Timothy Murphy offers a critical response . Elsewhere, Tak Chan and Stark & Delatycki debate the role of medical professionals in providing parentage determination. Chan argues that doctors are obliged to provide parentage tests when this is requested by parents, provided there is (...)
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  33.  54
    Negation in Negationless Intuitionistic Mathematics.Thomas Macaulay Ferguson - 2023 - Philosophia Mathematica 31 (1):29-55.
    The mathematician G.F.C. Griss is known for his program of negationless intuitionistic mathematics. Although Griss’s rejection of negation is regarded as characteristic of his philosophy, this is a consequence of an executability requirement that mental constructions presuppose agents’ executing corresponding mental activity. Restoring Griss’s executability requirement to a central role permits a more subtle characterization of the rejection of negation, according to which D. Nelson’s strong constructible negation is compatible with Griss’s principles. This exposes a ‘holographic’ theory of negation in (...)
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  34. (1 other version)G. E. Moore.Thomas Baldwin - 1991 - Mind 100 (3):376-379.
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  35.  43
    Conceptualism and the Objection from Animals.Thomas Land - 2018 - In Violetta L. Waibel, Margit Ruffing & David Wagner (eds.), Natur und Freiheit: Akten des XII. Internationalen Kant-Kongresses. De Gruyter. pp. 1269-1276.
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  36.  34
    Plato's Euthydemus: Analysis of what is and is Not Philosophy.Thomas H. Chance - 1992 - University of California Press.
    "We must turn to the Euthydemus if we are to understand both Plato's earlier and his more mature work. Thomas Chance's book is an indispensible tool for penetrating to the sources of Plato's thinking on the nature of philosophy. This is the most impressive treatment of the dialogue so far available to scholars, and the interpretations offered will surely be the starting point for all future discussions."--G. B. Kerferd, Emeritus, University of Manchester "A sensitive and well-informed study of an (...)
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  37.  30
    Culture follows design: Code design as an antecedent of the ethical culture.Thomas Stöber, Peter Kotzian & Barbara E. Weißenberger - 2018 - Business Ethics: A European Review 28 (1):112-128.
    Codes of ethics are directly aimed at behavioral control, but they also affect a company’s ethical culture, which in turn concerns compliance and ethical behavior. To positively influence a company’s ethical culture, employees must be familiar with its code of ethics, perceive that top management is committed to the code, and believe that their peers also comply with the code. The evidence on whether a code’s design affects a company’s ethical culture is limited. This study’s factorial survey experiment contributes to (...)
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  38.  4
    Medical ethics.Thomas Percival - 1927 - Huntington, N.Y.,: R. E. Krieger Pub. Co..
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  39.  21
    Symmetry and the evolution of the modular linguistic mind.Thomas Wynn - 2000 - In Peter Carruthers & Andrew Chamberlain (eds.), Evolution and the Human Mind: Modularity, Language and Meta-Cognition. Cambridge University Press. pp. 113--39.
  40.  53
    Time and the Foundations of Quantum Mechanics.Thomas Pashby - unknown
    Quantum mechanics has provided philosophers of science with many counterintuitive insights and interpretive puzzles, but little has been written about the role that time plays in the theory. One reason for this is the celebrated argument of Wolfgang Pauli against the inclusion of time as an observable of the theory, which has been seen as a demonstration that time may only enter the theory as a classical parameter. Against this orthodoxy I argue that there are good reasons to expect certain (...)
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  41. Cosmic processes and the nature of time.Thomas Gold - 1966 - In Robert Garland Colodny (ed.), Mind and Cosmos: Essays in Contemporary Science and Philosophy. [Pittsburgh]: University of Pittsburgh Press. pp. 329.
     
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  42.  29
    “Quite Artificial, Awkward, and Unnecessarily Neologistic”: Early Phenomenology and Psychology Arguing About the Fundamentals of Aesthetics.Thomas Petraschka - 2023 - Journal of Aesthetics and Phenomenology 10 (2):127-141.
    As phenomenology rose to prominence at the beginning of the 20th century, several aestheticians tried to establish the Husserlian method of “phenomenological reduction” in the field of aesthetics. These ventures were met with resistance from psychological aesthetics, which was the predominant form of aesthetics in the German-speaking world at the time. This paper examines, first, practical attempts to apply the method of “phenomenological reduction” in aesthetics. Using Waldemar Conrad and Moritz Geiger as examples, I try to trace what aestheticians actually (...)
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  43.  45
    Using Category Structures to Test Iterated Learning as a Method for Identifying Inductive Biases.Thomas L. Griffiths, Brian R. Christian & Michael L. Kalish - 2008 - Cognitive Science 32 (1):68-107.
    Many of the problems studied in cognitive science are inductive problems, requiring people to evaluate hypotheses in the light of data. The key to solving these problems successfully is having the right inductive biases—assumptions about the world that make it possible to choose between hypotheses that are equally consistent with the observed data. This article explores a novel experimental method for identifying the biases that guide human inductive inferences. The idea behind this method is simple: This article uses the responses (...)
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  44. Constructing a social contract for business.Thomas Donaldson - 2001 - In Alan R. Malachowski (ed.), Business ethics: critical perspectives on business and management. New York: Routledge. pp. 1--209.
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  45. Happiness and Human Flourishing in Kant's Ethics: THOMAS E. HILL, JR.Thomas E. Hill - 1999 - Social Philosophy and Policy 16 (1):143-175.
    Ancient moral philosophers, especially Aristotle and his followers, typically shared the assumption that ethics is primarily concerned with how to achieve the final end for human beings, a life of “happiness” or “human flourishing.” This final end was not a subjective condition, such as contentment or the satisfaction of our preferences, but a life that could be objectively determined to be appropriate to our nature as human beings. Character traits were treated as moral virtues because they contributed well toward this (...)
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  46.  50
    The Meaning of Philo's Reversal.Thomas Holden - 2023 - Journal of the History of Philosophy 61 (2):215-235.
    Abstractabstract:There are two ways of hearing Philo's unexpected endorsement of a version of the design hypothesis in the final part of Hume's Dialogues. We might register it in accordance with Cleanthes's descriptivist approach to religious speech, taking Philo to be reasoning with Cleanthes in Cleanthes's own way. Or we might hear Philo's words in accordance with his own expressivist account of religious speech, an account that Philo appears to have borrowed from Hobbes. I argue that Hume intended this double layering (...)
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  47. Making war on terrorists—reflections on Harming the innocent.Thomas Pogge - 2007 - Journal of Political Philosophy 16 (1):1–25.
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  48.  21
    Conceptualising Suspended Life: From Latency to Liminality.Thomas Lemke - 2023 - Theory, Culture and Society 40 (6):69-86.
    The article focuses on the ability of some animals and plants to respond to changing environmental conditions by temporarily suspending metabolic processes. In contemporary biology, this state between life and death is commonly labelled ‘cryptobiosis’, combining the Greek kryptos (hidden, concealed, secret) with biōsis (mode of life). I argue that the notion of ‘cryptobiosis’ does not account sufficiently for the processual and relational dimensions of ametabolic life. The article advances a related but different concept, which better addresses this liminal state (...)
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  49. In defense of inner sense: Aristotle on perceiving that one sees.Thomas Johansen - 2005 - Proceedings of the Boston Area Colloquium of Ancient Philosophy 21:235-276.
  50. The Unmitigated Scotus.Thomas Williams - 1998 - Archiv für Geschichte der Philosophie 80 (2):162-181.
    Scotus is notorious for occasionally making statements that, on their face at least, smack of voluntarism, but there has been a lively debate about whether Scotus is really a voluntarist after all. Now the debate is not over whether Scotus lays great emphasis on the role of the divine will with respect to the moral law. No one could sensibly deny that he does, and if such an emphasis constitutes voluntarism, then no one could sensibly deny that Scotus is a (...)
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